Le SIDA au Ghana (serveur d'exploration)

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AIDS in an HIV‐seronegative Ghanaian woman with intersubtype A/G recombinant HIV‐1 infection

Identifieur interne : 001169 ( Main/Exploration ); précédent : 001168; suivant : 001170

AIDS in an HIV‐seronegative Ghanaian woman with intersubtype A/G recombinant HIV‐1 infection

Auteurs : Daniel Candotti [Royaume-Uni] ; Yaw Adu-Sarkodie [Ghana] ; Fiona Davies [Royaume-Uni] ; Eva Baldrich-Rubio [Royaume-Uni] ; Kathleen Stirrups [Royaume-Uni] ; Helen Lee [Royaume-Uni] ; Jean-Pierre Allain [Royaume-Uni]

Source :

RBID : ISTEX:BAB7189089E6E0449BC45B882663FA86FC0801FE

Descripteurs français

English descriptors

Abstract

A 29‐year‐old Ghanaian woman who developed AIDS while being HIV‐antibody seronegative was investigated during a collaborative study aimed at the identification of viral causes of a HIV‐seronegative AIDS syndrome in West Africa. Plasma was screened with a panel of EIA tests for antibodies to HIV and HIV‐1 p24 antigen. Retroviral infection was investigated by detection of reverse transcriptase (RT) activity in plasma, viral RNA amplification and quantification, and virus isolation. Positive amplification products were sequenced and phylogenetic analyses were carried out. Most EIA tests were unable to demonstrate the presence of anti‐HIV anti‐bodies, whereas confirmatory assays yielded inconclusive results. Retroviral infection was documented by detection of RT activity, HIV‐1‐specific genomic amplification and virus isolation. This virus was HIV‐1 subtype A with an unusual six amino acid insertion in the gp120 V4 loop and with the nef gene of subtype G. The patient's plasma did not react with either autologous or heterologous viral lysates or HIV‐1 peptides, whereas antibodies to other viral antigens were present. In conclusion, the Ghanaian patient exhibited a rare subtype A/G recombinant HIV‐1 infection with a near absence of a HIV‐specific humoral response. The lack of detectable antibody response might be due to either a highly pathogenic, rapidly fatal, HIV‐1 infection preventing the development of the typical humoral immune response or to a host‐related dysfunction of the immune system. Direct antigenemia or genomic detection of the virus should be undertaken when clinical or biological data suggests an HIV infection in the absence of serological evidence. J. Med. Virol. 62:1–8, 2000. © 2000 Wiley‐Liss, Inc.

Url:
DOI: 10.1002/1096-9071(200009)62:1<1::AID-JMV1>3.0.CO;2-3


Affiliations:


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Le document en format XML

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<term>Acquired Immunodeficiency Syndrome (diagnosis)</term>
<term>Acquired Immunodeficiency Syndrome (immunology)</term>
<term>Acquired Immunodeficiency Syndrome (virology)</term>
<term>Adult</term>
<term>Aids syndrome</term>
<term>Amino</term>
<term>Amino Acid Sequence</term>
<term>Amino acid</term>
<term>Amino acid sequences</term>
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<term>Antibody production</term>
<term>Assay</term>
<term>Bdna method</term>
<term>Biological data</term>
<term>Biological phenotype</term>
<term>Blotting, Western</term>
<term>CD4 Lymphocyte Count</term>
<term>Candotti</term>
<term>Case study</term>
<term>Cell count</term>
<term>Cell cultures</term>
<term>Cell line cultures</term>
<term>Clinical criteria</term>
<term>Clinical symptoms</term>
<term>Collaborative study</term>
<term>Confirmatory assays</term>
<term>Consensus sequences</term>
<term>Culture supernatants</term>
<term>Detectable antibody response</term>
<term>Envelope glycoprotein</term>
<term>Faint band</term>
<term>Female</term>
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<term>Genetic systems</term>
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<term>Genomic detection</term>
<term>Genotype</term>
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<term>HIV Core Protein p24 (blood)</term>
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<term>HIV Reverse Transcriptase (blood)</term>
<term>HIV Seronegativity (genetics)</term>
<term>HIV-1 (genetics)</term>
<term>HIV-1 (isolation & purification)</term>
<term>HIV-1 virus</term>
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<term>High levels</term>
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<term>Human immunodeficiency virus type</term>
<term>Human leukemia virus type</term>
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<term>Humoral immunity</term>
<term>Humoral response</term>
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<term>Immune system</term>
<term>Immunodeficiency</term>
<term>Immunodeficiency virus type</term>
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<term>Infectious agents</term>
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<term>Phylogenetic analyses</term>
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<term>Polymerase chain reaction</term>
<term>Primary culture</term>
<term>Primer</term>
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<term>Rapid progression</term>
<term>Recombinant</term>
<term>Recombinant cell lines</term>
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<term>Retrovirus</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Sequence Alignment</term>
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<term>Serology</term>
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<term>Seronegativity</term>
<term>Significant difference</term>
<term>Simian immunodeficiency virus</term>
<term>Specific antibodies</term>
<term>Subtype</term>
<term>Transcriptase assay</term>
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<term>Viral</term>
<term>Viral causes</term>
<term>Virol</term>
<term>Virol candotti</term>
<term>Virus</term>
<term>Virus isolation</term>
<term>Virus replication properties</term>
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<term>West african patients</term>
<term>Western blot</term>
<term>Window period</term>
<term>nef Gene Products, Human Immunodeficiency Virus</term>
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<term>Adulte</term>
<term>Alignement de séquences</term>
<term>Anticorps anti-VIH (sang)</term>
<term>Antigènes HLA (sang)</term>
<term>Données de séquences moléculaires</term>
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<term>Produits du gène nef du virus de l'immunodéficience humaine</term>
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<term>Recombinaison génétique</term>
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<term>Séquence d'acides aminés</term>
<term>Séronégativité VIH (génétique)</term>
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<term>Techniques immunoenzymatiques</term>
<term>Transcriptase inverse du VIH (sang)</term>
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<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term>
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<term>Gene Products, nef</term>
<term>HIV Antibodies</term>
<term>HIV Core Protein p24</term>
<term>HIV Envelope Protein gp120</term>
<term>HIV Reverse Transcriptase</term>
<term>HLA Antigens</term>
<term>RNA, Viral</term>
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<term>Ghana</term>
<term>nef Gene Products, Human Immunodeficiency Virus</term>
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<term>Syndrome d'immunodéficience acquise</term>
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<term>HIV-1</term>
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<term>Syndrome d'immunodéficience acquise</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Acquired Immunodeficiency Syndrome</term>
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<term>HIV-1</term>
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<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr">
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
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<term>ARN viral</term>
<term>Anticorps anti-VIH</term>
<term>Antigènes HLA</term>
<term>Produits du gène nef</term>
<term>Protéine d'enveloppe gp120 du VIH</term>
<term>Protéine de capside p24 du VIH</term>
<term>Transcriptase inverse du VIH</term>
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<term>Syndrome d'immunodéficience acquise</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Acquired Immunodeficiency Syndrome</term>
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<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Amino Acid Sequence</term>
<term>Blotting, Western</term>
<term>CD4 Lymphocyte Count</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Immunoenzyme Techniques</term>
<term>Molecular Sequence Data</term>
<term>Recombination, Genetic</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Sequence Alignment</term>
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<keywords scheme="Pascal" xml:lang="fr">
<term>Adulte</term>
<term>Alignement de séquences</term>
<term>Anticorps</term>
<term>Données de séquences moléculaires</term>
<term>Etude cas</term>
<term>Femelle</term>
<term>Ghana</term>
<term>Génotype</term>
<term>Homme</term>
<term>Humains</term>
<term>Immunité humorale</term>
<term>Numération des lymphocytes CD4</term>
<term>Produits du gène nef du virus de l'immunodéficience humaine</term>
<term>RT-PCR</term>
<term>Recombinaison génétique</term>
<term>SIDA</term>
<term>Séquence d'acides aminés</term>
<term>Sérologie</term>
<term>Séronégativité</term>
<term>Technique de Western</term>
<term>Techniques immunoenzymatiques</term>
<term>Virus HIV1</term>
<term>Virus recombinant</term>
</keywords>
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<term>Aids syndrome</term>
<term>Amino</term>
<term>Amino acid</term>
<term>Amino acid sequences</term>
<term>Amino acids</term>
<term>Amplification</term>
<term>Antibody</term>
<term>Antibody production</term>
<term>Assay</term>
<term>Bdna method</term>
<term>Biological data</term>
<term>Biological phenotype</term>
<term>Candotti</term>
<term>Cell count</term>
<term>Cell cultures</term>
<term>Cell line cultures</term>
<term>Clinical criteria</term>
<term>Clinical symptoms</term>
<term>Collaborative study</term>
<term>Confirmatory assays</term>
<term>Consensus sequences</term>
<term>Culture supernatants</term>
<term>Detectable antibody response</term>
<term>Envelope glycoprotein</term>
<term>Faint band</term>
<term>Genetic systems</term>
<term>Genomic amplification</term>
<term>Genomic detection</term>
<term>Ghanaian patient</term>
<term>Ghanaian woman</term>
<term>High level</term>
<term>High levels</term>
<term>Human immunodeficiency virus type</term>
<term>Human leukemia virus type</term>
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<term>Immune</term>
<term>Immune system</term>
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<term>Immunodeficiency virus type</term>
<term>Immunosilent aids</term>
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<term>Infectious agents</term>
<term>Komfo anokye teaching hospital</term>
<term>Peptide</term>
<term>Phylogenetic analyses</term>
<term>Plasma</term>
<term>Polymerase chain reaction</term>
<term>Primary culture</term>
<term>Primer</term>
<term>Rapid disease progression</term>
<term>Rapid progression</term>
<term>Recombinant</term>
<term>Recombinant cell lines</term>
<term>Replication</term>
<term>Retroviral infection</term>
<term>Retrovirus</term>
<term>Room temperature</term>
<term>Serological evidence</term>
<term>Seronegative</term>
<term>Significant difference</term>
<term>Simian immunodeficiency virus</term>
<term>Specific antibodies</term>
<term>Subtype</term>
<term>Transcriptase assay</term>
<term>Typical humoral</term>
<term>Viral</term>
<term>Viral causes</term>
<term>Virol</term>
<term>Virol candotti</term>
<term>Virus</term>
<term>Virus isolation</term>
<term>Virus replication properties</term>
<term>West africa</term>
<term>West african patients</term>
<term>Western blot</term>
<term>Window period</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr">
<term>Ghana</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">A 29‐year‐old Ghanaian woman who developed AIDS while being HIV‐antibody seronegative was investigated during a collaborative study aimed at the identification of viral causes of a HIV‐seronegative AIDS syndrome in West Africa. Plasma was screened with a panel of EIA tests for antibodies to HIV and HIV‐1 p24 antigen. Retroviral infection was investigated by detection of reverse transcriptase (RT) activity in plasma, viral RNA amplification and quantification, and virus isolation. Positive amplification products were sequenced and phylogenetic analyses were carried out. Most EIA tests were unable to demonstrate the presence of anti‐HIV anti‐bodies, whereas confirmatory assays yielded inconclusive results. Retroviral infection was documented by detection of RT activity, HIV‐1‐specific genomic amplification and virus isolation. This virus was HIV‐1 subtype A with an unusual six amino acid insertion in the gp120 V4 loop and with the nef gene of subtype G. The patient's plasma did not react with either autologous or heterologous viral lysates or HIV‐1 peptides, whereas antibodies to other viral antigens were present. In conclusion, the Ghanaian patient exhibited a rare subtype A/G recombinant HIV‐1 infection with a near absence of a HIV‐specific humoral response. The lack of detectable antibody response might be due to either a highly pathogenic, rapidly fatal, HIV‐1 infection preventing the development of the typical humoral immune response or to a host‐related dysfunction of the immune system. Direct antigenemia or genomic detection of the virus should be undertaken when clinical or biological data suggests an HIV infection in the absence of serological evidence. J. Med. Virol. 62:1–8, 2000. © 2000 Wiley‐Liss, Inc.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Ghana</li>
<li>Royaume-Uni</li>
</country>
<region>
<li>Angleterre</li>
<li>Angleterre de l'Est</li>
</region>
<settlement>
<li>Cambridge</li>
</settlement>
<orgName>
<li>Université de Cambridge</li>
</orgName>
</list>
<tree>
<country name="Royaume-Uni">
<region name="Angleterre">
<name sortKey="Candotti, Daniel" sort="Candotti, Daniel" uniqKey="Candotti D" first="Daniel" last="Candotti">Daniel Candotti</name>
</region>
<name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
<name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
<name sortKey="Baldrich Ubio, Eva" sort="Baldrich Ubio, Eva" uniqKey="Baldrich Ubio E" first="Eva" last="Baldrich-Rubio">Eva Baldrich-Rubio</name>
<name sortKey="Davies, Fiona" sort="Davies, Fiona" uniqKey="Davies F" first="Fiona" last="Davies">Fiona Davies</name>
<name sortKey="Lee, Helen" sort="Lee, Helen" uniqKey="Lee H" first="Helen" last="Lee">Helen Lee</name>
<name sortKey="Stirrups, Kathleen" sort="Stirrups, Kathleen" uniqKey="Stirrups K" first="Kathleen" last="Stirrups">Kathleen Stirrups</name>
</country>
<country name="Ghana">
<noRegion>
<name sortKey="Adu Arkodie, Yaw" sort="Adu Arkodie, Yaw" uniqKey="Adu Arkodie Y" first="Yaw" last="Adu-Sarkodie">Yaw Adu-Sarkodie</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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